Cortical activity in Parkinson's disease during executive processing depends on striatal involvement
Identifieur interne : 001331 ( Main/Exploration ); précédent : 001330; suivant : 001332Cortical activity in Parkinson's disease during executive processing depends on striatal involvement
Auteurs : Oury Monchi [Canada] ; Michael Petrides [Canada] ; Beatriz Mejia-Constain [Canada] ; Antonio P. Strafella [Canada]Source :
- Brain [ 0006-8950 ] ; 2007-01.
Abstract
Patients with idiopathic Parkinson's disease exhibit impairments in executive processes, including planning and set-shifting, even at the early stages of the disease. We have recently developed a new card-sorting task to study the specific role of the caudate nucleus in such executive processes and have shown, using functional magnetic resonance imaging (fMRI) in young healthy adults, that the caudate nucleus is specifically required when a set-shift must be planned. Here the same fMRI protocol was used to compare the patterns of activation in a group of early-stage Parkinson's disease patients (seven right-handed patients at Hoehn and Yahr stages 1 and 2; mean age 62 years, range 56–70) and matched control subjects. Increased cortical activation was observed in the patients compared with the control group in the condition not specifically requiring the caudate nucleus. On the other hand, decreased cortical activation was observed in the patient group in the condition significantly involving the caudate nucleus. This event-related fMRI study showed a pattern of cortical activation in Parkinson's disease characterized by either reduced or increased activation depending on whether the caudate nucleus was involved or not in the task. This activation pattern included not only the prefrontal regions but also posterior cortical areas in the parietal and prestriate cortex. These findings are not in agreement with the traditional model, which proposes that the nigrostriatal dopamine depletion results in decreased cortical activity. These observations provide further evidence in favour of the hypothesis that not only the nigrostriatal and but also the mesocortical dopaminergic substrate may play a significant role in the cognitive deficits observed in Parkinson's disease.
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DOI: 10.1093/brain/awl326
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Strafella</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DAF2594EC525CE37FDFE4E02480F3C02C102A4E1</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1093/brain/awl326</idno><idno type="url">https://api.istex.fr/document/DAF2594EC525CE37FDFE4E02480F3C02C102A4E1/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002065</idno><idno type="wicri:Area/Main/Curation">001D64</idno><idno type="wicri:Area/Main/Exploration">001331</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cortical activity in Parkinson's disease during executive processing depends on striatal involvement</title><author><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><affiliation><wicri:noCountry code="subField">Quebec</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Quebec</wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Correspondence to: Oury Monchi, PhD, Centre de recherche, Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Road, Montreal, H3W 1W5, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Petrides, Michael" sort="Petrides, Michael" uniqKey="Petrides M" first="Michael" last="Petrides">Michael Petrides</name><affiliation><wicri:noCountry code="subField">Quebec</wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Correspondence to: Oury Monchi, PhD, Centre de recherche, Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Road, Montreal, H3W 1W5, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Mejia Constain, Beatriz" sort="Mejia Constain, Beatriz" uniqKey="Mejia Constain B" first="Beatriz" last="Mejia-Constain">Beatriz Mejia-Constain</name><affiliation><wicri:noCountry code="subField">Quebec</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Quebec</wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Correspondence to: Oury Monchi, PhD, Centre de recherche, Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Road, Montreal, H3W 1W5, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. 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We have recently developed a new card-sorting task to study the specific role of the caudate nucleus in such executive processes and have shown, using functional magnetic resonance imaging (fMRI) in young healthy adults, that the caudate nucleus is specifically required when a set-shift must be planned. Here the same fMRI protocol was used to compare the patterns of activation in a group of early-stage Parkinson's disease patients (seven right-handed patients at Hoehn and Yahr stages 1 and 2; mean age 62 years, range 56–70) and matched control subjects. Increased cortical activation was observed in the patients compared with the control group in the condition not specifically requiring the caudate nucleus. On the other hand, decreased cortical activation was observed in the patient group in the condition significantly involving the caudate nucleus. This event-related fMRI study showed a pattern of cortical activation in Parkinson's disease characterized by either reduced or increased activation depending on whether the caudate nucleus was involved or not in the task. This activation pattern included not only the prefrontal regions but also posterior cortical areas in the parietal and prestriate cortex. These findings are not in agreement with the traditional model, which proposes that the nigrostriatal dopamine depletion results in decreased cortical activity. These observations provide further evidence in favour of the hypothesis that not only the nigrostriatal and but also the mesocortical dopaminergic substrate may play a significant role in the cognitive deficits observed in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name></noRegion><name sortKey="Mejia Constain, Beatriz" sort="Mejia Constain, Beatriz" uniqKey="Mejia Constain B" first="Beatriz" last="Mejia-Constain">Beatriz Mejia-Constain</name><name sortKey="Petrides, Michael" sort="Petrides, Michael" uniqKey="Petrides M" first="Michael" last="Petrides">Michael Petrides</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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